Calcified Tissue International and Musculoskeletal Research is a leading peer-reviewed journal which publishes high-impact original research focusing on preclinical, translational, and clinical bone and musculoskeletal research.

The Journal Editors, Professor René Rizzoli and Professor Stuart Ralston are now pleased to announce the top 10 most impactful papers of 2021-2021. The authors of each of these outstanding papers have been recognized with certificates of publishing excellence. The Editors stated:

“We sincerely thank the contributing authors for their high-quality research papers, all of which have contributed to the journal’s increasing impact factor and status as a leading platform for state-of-the-art research.”

We invite you to read, cite and share these high-impact papers (all either open access or freely accessible until April 28, 2023): 

• Ishimoto, T., et al. Quantitative Evaluation of Osteocyte Morphology and Bone Anisotropic Extracellular Matrix in Rat Femur. Calcif Tissue Int 109, 434–444 (2021). 
   
• Ito, N., et al. Sclerostin Directly Stimulates Osteocyte Synthesis of Fibroblast Growth Factor-23. Calcif Tissue Int 109, 66–76 (2021).   
   
• Badraoui, R., et al. Expression Profiling of Selected Immune Genes and Trabecular Microarchitecture in Breast Cancer Skeletal Metastases Model: Effect of α–Tocopherol Acetate Supplementation. Calcif Tissue Int 110, 475–488 (2022).
   
• Taylor, E.A., et al. Measures of Bone Mineral Carbonate Content and Mineral Maturity/Crystallinity for FT-IR and Raman Spectroscopic Imaging Differentially Relate to Physical–Chemical Properties of Carbonate-Substituted Hydroxyapatite. Calcif Tissue Int 109, 77–91 (2021). 
   
• Christodoulou, M., et al. Vitamin D Supplementation for Patients with Chronic Kidney Disease: A Systematic Review and Meta-analyses of Trials Investigating the Response to Supplementation and an Overview of Guidelines. Calcif Tissue Int 109, 157–178 (2021).
   
• He, B., et al. Depression and Osteoporosis: A Mendelian Randomization Study. Calcif Tissue Int 109, 675–684 (2021). 
   
• Wang, N., et al. Gut Microbiota Dysbiosis as One Cause of Osteoporosis by Impairing Intestinal Barrier Function. Calcif Tissue Int 110, 225–235 (2022). 
   
• Padidela, R., et al. Patient-Reported Outcomes from a Randomized, Active-Controlled, Open-Label, Phase 3 Trial of Burosumab Versus Conventional Therapy in Children with X-Linked Hypophosphatemia. Calcif Tissue Int 108, 622–633 (2021). 
   
• Kerschan-Schindl, K., et al. Diagnostic Performance of a Panel of miRNAs (OsteomiR) for Osteoporosis in a Cohort of Postmenopausal Women. Calcif Tissue Int 108, 725–737 (2021).
   
• Abrahamsen, B., et al. Epidemiology of Tumor-Induced Osteomalacia in Denmark. Calcif Tissue Int 109, 147–156 (2021). 

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About Calcified Tissue International & Musculoskeletal Research
Calcified Tissue International & Musculoskeletal Research is a peer-reviewed journal which publishes original preclinical, translational and clinical research, and reviews concerning the structure and function of bone, and other musculoskeletal tissues in living organisms, as well as clinical studies of musculoskeletal disease. It includes studies of cell biology, molecular biology, intracellular signalling, and physiology, as well as research into the hormones, cytokines and other mediators that influence the musculoskeletal system. The journal also publishes clinical studies of relevance to bone disease, mineral metabolism, muscle function, and musculoskeletal interactions. 
2021 Impact Factor: 4.000; 5-Year Impact Factor: 4.227
https://www.springer.com/journal/223   

Editors in Chief: Stuart Ralston and René Rizzoli; Musculoskeletal Research Section Editor: Roger Fielding

About IOF
The International Osteoporosis Foundation (IOF) is the world's largest nongovernmental organization dedicated to the prevention, diagnosis and treatment of osteoporosis and related musculoskeletal diseases. IOF members, including committees of scientific researchers as well as more than 310 patient, medical and research organizations, work together to make fracture prevention and healthy mobility a worldwide heath care priority. https://www.osteoporosis.foundation @iofbonehealth