Chairs: S Ferrari, C Meier

Members: B Abrahamsen, K Akesson, N Al-Daghri, M Chakthoura, M Chandran, R Eastell, G El Hajj Fuleihan, B Josse, D Kendler, N Lane, B Leslie, A Mithal, N Napoli, A Suzuki, S Vasikaran

To give guidance on the diagnosis and management of osteoporosis in the context of diabetes.

Biochemical markers of bone fragility in diabetes: to review the current understanding of the pathophysiological mechanisms underlying bone fragility in diabetes mellitus with specific focus on biochemical markers reflecting cellular and molecular changes in diabetic bone.

1. Ferrari SL, Abrahamsen B, Napoli N, Akesson K, Chandran M, Eastell R, El-Hajj Fuleihan G, Josse R, Kendler DL, Kraenzlin M, Suzuki A, Pierroz DD, Schwartz AV, Leslie WD; Bone and Diabetes Working Group of IOF. Diagnosis and management of bone fragility in diabetes: an emerging challenge. Osteoporos Int. 2018 Dec;29(12):2585-2596. doi: 10.1007/s00198-018-4650-2.
2. Ferrari SL, Abrahamsen B, Napoli N, Akesson K, Chandran M, Eastell R, El-Hajj Fuleihan G, Josse R, Kendler DL, Kraenzlin M, Suzuki A, Pierroz DD, Schwartz AV, Leslie WD, on behalf of the Bone and Diabetes Working Group of IOF. Diagnosis and Management of Bone Fragility in Diabetes: An Emerging Challenge – A Short Review. Journal of Diabetes Management and Metabolism
3. Ferrari, S.L., et al., Diagnosis and management of bone fragility in diabetes: an emerging challenge. Osteoporos Int, 2018. 29(12): p. 2585-2596.
4. Napoli, N., et al., Mechanisms of diabetes mellitus-induced bone fragility. Nat Rev Endocrinol, 2017. 13(4): p. 208-219.
5. Hough, F.S., et al., MECHANISMS IN ENDOCRINOLOGY: Mechanisms and evaluation of bone fragility in type 1 diabetes mellitus. Eur J Endocrinol, 2016. 174(4): p. R127-38.