Working Groups

Standardisation of Bone Marker Assays as a part of the IFCC Committee Bone Metabolism (C-BM)

Members

Chairs: E Cavalier

Members:
IOF: K Åkesson, O Bruyère, C Cooper, R Eastell, J Foldes, P Garnero, NR Jørgensen, JA Kanis, P Khashayar, N Lane, M McClung, S Silverman
IFCC: HP Bhattoa, V Delatour, A Griesmacher, A Heijboer, M Lorentzon, C Sempos, C Sturgeon, C Ulmer, S Vasikaran, H Vesper

Aim

This working group seeks to identify consensus reference standard bone resorption marker and bone formation marker for fracture risk assessment and monitoring of osteoporosis treatment.

Objectives

  • Harmonisation and standardisation of selected bone markers (CTX and P1NP)
  • Clinical usefulness of bone turnover marker levels

Related content

Bone Turnover Markers Educational Course

Publications

  1. Cavalier, E., et al., A multicenter study to evaluate harmonization of assays for N-terminal propeptide of type I procollagen (PINP): a report from the IFCC-IOF Joint Committee for Bone Metabolism. Clin Chem Lab Med, 2019. 
  2. Morris, H.A., et al., Clinical usefulness of bone turnover marker concentrations in osteoporosis. Clin Chim Acta, 2017. 467: p. 34-41.
  3. Johansson, H., et al., A meta-analysis of reference markers of bone turnover for prediction of fracture. Calcif Tissue Int, 2014. 94(5): p. 560-7.
  4. Vasikaran, S.D., C. Cooper, and J.A. Kanis, Recommendations for bone marker standards in osteoporosis: what, why and where to now? Ann Clin Biochem, 2011. 48(Pt 2): p. 91-2.
  5. Vasikaran, S., et al., Markers of bone turnover for the prediction of fracture risk and monitoring of osteoporosis treatment: a need for international reference standards. Osteoporos Int, 2011. 22(2): p. 391-420.
  6. Vasikaran, S., et al., International Osteoporosis Foundation and International Federation of Clinical Chemistry and Laboratory Medicine position on bone marker standards in osteoporosis. Clin Chem Lab Med, 2011. 49(8): p. 1271-4.